The Central Carolina Community College Lee Main Campus, which is home to the college’s administrative offices, has grown substantially since its beginnings in 1961. Among the most recent additions to the campus is the E. Eugene Moore Manufacturing and Biotech Solutions Center, the site of a former manufacturing facility.

Programs at the Lee Main Campus include university transfer programs, as well as a variety of career and technical programs in the following Career Communities: Applied Technologies, Arts, Business Technologies, Health Sciences, Professional Services, Public Safety and STEM.

Campus facilities include the Dalrymple Veterinary Medical Technology Building – home to the 十大外围足彩排行榜 VMT program, and the Keller Health Sciences Building – home to the 十大外围足彩排行榜 Dental and Nursing programs.

Also on the campus is the Dennis A. Wicker Civic & Conference Center, which is operated by the college.